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Is Type-2 Diabetes a Glycogen Storage Disease of Pancreatic β-Cells?
Elevated plasma glucose leads to pancreatic β-cell dysfunction and death in type 2 diabetes. Glycogen accumulation, due to impaired metabolism, contributes to this ‘glucotoxicity’ via dysregulated biochemical pathways promoting β-cell dysfunction. Here, we review emerging data, and re-examine publis...
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| Vydáno v: | Cell Metab |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5890904/ https://ncbi.nlm.nih.gov/pubmed/28683284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.05.014 |
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