The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells

BACKGROUND: The fusion protein RUNX1-CBFA2T1 associated with t(8;21)-positive acute myeloid leukaemia is a potent inhibitor of haematopoetic differentiation. The role of RUNX1-CBFA2T1 in leukaemic cell proliferation is less clear. We examined the consequences of siRNA-mediated RUNX1-CBFA2T1 depletio...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Martinez, Natalia, Drescher, Bettina, Riehle, Heidemarie, Cullmann, Claire, Vornlocher, Hans-Peter, Ganser, Arnold, Heil, Gerhard, Nordheim, Alfred, Krauter, Jürgen, Heidenreich, Olaf
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC512292/
https://ncbi.nlm.nih.gov/pubmed/15298716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-4-44
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados