Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases

Mevalonate kinase deficiency (MKD) is caused by mutations in a key enzyme of the mevalonate–cholesterol biosynthesis pathway, leading to recurrent autoinflammatory disease characterised by enhanced release of interleukin-1β (IL-1β). It is currently believed that the inflammatory phenotype of MKD is...

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Detalhes bibliográficos
Publicado no:Immunol Cell Biol
Main Authors: Jurczyluk, Julie, Munoz, Marcia A, Skinner, Oliver P, Chai, Ryan C, Ali, Naveid, Palendira, Umaimainthan, Quinn, Julian MW, Preston, Alexandra, Tangye, Stuart G, Brown, Andrew J, Argent, Elizabeth, Ziegler, John B, Mehr, Sam, Rogers, Michael J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5122740/
https://ncbi.nlm.nih.gov/pubmed/27377765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2016.58
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