A highly sensitive prenylation assay reveals in vivo effects of bisphosphonate drug on the Rab prenylome of macrophages outside the skeleton

Bisphosphonate drugs such as zoledronic acid (ZOL), used for the treatment of common bone disorders, target the skeleton and inhibit bone resorption by preventing the prenylation of small GTPases in bone-destroying osteoclasts. Increasing evidence indicates that bisphosphonates also have pleiotropic...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Small GTPases
Prif Awduron: Ali, Naveid, Jurczyluk, Julie, Shay, Gemma, Tnimov, Zakir, Alexandrov, Kirill, Munoz, Marcia A, Skinner, Oliver P, Pavlos, Nathan J, Rogers, Michael J
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2015
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905276/
https://ncbi.nlm.nih.gov/pubmed/26399387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2015.1085485
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