A highly sensitive prenylation assay reveals in vivo effects of bisphosphonate drug on the Rab prenylome of macrophages outside the skeleton

Bisphosphonate drugs such as zoledronic acid (ZOL), used for the treatment of common bone disorders, target the skeleton and inhibit bone resorption by preventing the prenylation of small GTPases in bone-destroying osteoclasts. Increasing evidence indicates that bisphosphonates also have pleiotropic...

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Bibliografiska uppgifter
I publikationen:Small GTPases
Huvudupphovsmän: Ali, Naveid, Jurczyluk, Julie, Shay, Gemma, Tnimov, Zakir, Alexandrov, Kirill, Munoz, Marcia A, Skinner, Oliver P, Pavlos, Nathan J, Rogers, Michael J
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2015
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905276/
https://ncbi.nlm.nih.gov/pubmed/26399387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2015.1085485
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