Focal Adhesion Kinase regulates the DNA damage response and its inhibition radiosensitizes mutant KRAS lung cancer

PURPOSE: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide due to limited availability of effective therapeutic options. For instance, there are no effective strategies for NSCLCs that harbor mutant KRAS, the most commonly mutated oncogene in NSCLC. Thus, our...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Tang, Ke-Jing, Constanzo, Jerfiz, Venkateswaran, Niranjan, Melegari, Margherita, Ilcheva, Mariya, Morales, Julio C., Skoulidis, Ferdinandos, Heymach, John V., Boothman, David A., Scaglioni, Pier Paolo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5122471/
https://ncbi.nlm.nih.gov/pubmed/27220963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2603
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