Downregulation of HSP60 disrupts mitochondrial proteostasis to promote tumorigenesis and progression in clear cell renal cell carcinoma

In the present study, we demonstrate that HSP60 is unequivocally downregulated in clear cell renal cell carcinoma (ccRCC) tissues compared to pericarcinous tissues. Overexpression of HSP60 in ccRCC cancer cells suppresses cell growth. HSP60 knockdown increases cell growth and proliferation in both c...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Tang, Haiping, Chen, Yuling, Liu, Xiaohui, Wang, Shiyu, Lv, Yang, Wu, Di, Wang, Qingtao, Luo, Minkui, Deng, Haiteng
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5122432/
https://ncbi.nlm.nih.gov/pubmed/27246978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9615
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