Downregulation of HSP60 disrupts mitochondrial proteostasis to promote tumorigenesis and progression in clear cell renal cell carcinoma

In the present study, we demonstrate that HSP60 is unequivocally downregulated in clear cell renal cell carcinoma (ccRCC) tissues compared to pericarcinous tissues. Overexpression of HSP60 in ccRCC cancer cells suppresses cell growth. HSP60 knockdown increases cell growth and proliferation in both c...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Tang, Haiping, Chen, Yuling, Liu, Xiaohui, Wang, Shiyu, Lv, Yang, Wu, Di, Wang, Qingtao, Luo, Minkui, Deng, Haiteng
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2016
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5122432/
https://ncbi.nlm.nih.gov/pubmed/27246978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9615
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