HSP60 silencing promotes Warburg-like phenotypes and switches the mitochondrial function from ATP production to biosynthesis in ccRCC cells

HSP60 is a major mitochondrial chaperone for maintaining mitochondrial proteostasis. Our previous studies showed that HSP60 was significantly downregulated in clear cell renal cell carcinoma (ccRCC), the most common type of kidney cancer characterized by the classic Warburg effect. Here, we analyzed...

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Vydáno v:Redox Biol
Hlavní autoři: Teng, Ruifang, Liu, Zongyuan, Tang, Haiping, Zhang, Wenhao, Chen, Yuling, Xu, Renhua, Chen, Liang, Song, Jiangping, Liu, Xiaohui, Deng, Haiteng
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
Témata:
Short Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526248/
https://ncbi.nlm.nih.gov/pubmed/31112866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101218
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