Downregulation of HSP60 disrupts mitochondrial proteostasis to promote tumorigenesis and progression in clear cell renal cell carcinoma

In the present study, we demonstrate that HSP60 is unequivocally downregulated in clear cell renal cell carcinoma (ccRCC) tissues compared to pericarcinous tissues. Overexpression of HSP60 in ccRCC cancer cells suppresses cell growth. HSP60 knockdown increases cell growth and proliferation in both c...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Tang, Haiping, Chen, Yuling, Liu, Xiaohui, Wang, Shiyu, Lv, Yang, Wu, Di, Wang, Qingtao, Luo, Minkui, Deng, Haiteng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2016
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5122432/
https://ncbi.nlm.nih.gov/pubmed/27246978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9615
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