Downregulation of HSP60 disrupts mitochondrial proteostasis to promote tumorigenesis and progression in clear cell renal cell carcinoma

In the present study, we demonstrate that HSP60 is unequivocally downregulated in clear cell renal cell carcinoma (ccRCC) tissues compared to pericarcinous tissues. Overexpression of HSP60 in ccRCC cancer cells suppresses cell growth. HSP60 knockdown increases cell growth and proliferation in both c...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Tang, Haiping, Chen, Yuling, Liu, Xiaohui, Wang, Shiyu, Lv, Yang, Wu, Di, Wang, Qingtao, Luo, Minkui, Deng, Haiteng
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5122432/
https://ncbi.nlm.nih.gov/pubmed/27246978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9615
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires