The mevalonate pathway regulates primitive streak formation via protein farnesylation

The primitive streak in peri-implantation embryos forms the mesoderm and endoderm and controls cell differentiation. The metabolic cues regulating primitive streak formation remain largely unknown. Here we utilised a mouse embryonic stem (ES) cell differentiation system and a library of well-charact...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Okamoto-Uchida, Yoshimi, Yu, Ruoxing, Miyamura, Norio, Arima, Norie, Ishigami-Yuasa, Mari, Kagechika, Hiroyuki, Yoshida, Suguru, Hosoya, Takamitsu, Nawa, Makiko, Kasama, Takeshi, Asaoka, Yoichi, Alois, Reiner Wimmer, Elling, Ulrich, Penninger, Josef M., Nishina, Sachiko, Azuma, Noriyuki, Nishina, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5121603/
https://ncbi.nlm.nih.gov/pubmed/27883036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37697
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