Medullary Thymic Epithelial Cells and CD8α(+) Dendritic Cells coordinately regulate central tolerance but CD8α(+) cells are Dispensable for Thymic Regulatory T cell production

In the thymus, antigen presenting cells (APCs) namely, medullary thymic epithelial cells (mTECs) and thymic dendritic cells (tDCs) regulate T cell tolerance through elimination of autoreactive T cells and production of thymic T regulatory (tTreg) cells. How the different APCs in the thymus share the...

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Détails bibliographiques
Publié dans:J Autoimmun
Auteurs principaux: Herbin, Olivier, Bonito, Anthony J., Jeong, Seihwan, Weinstein, Erica G., Rahman, Adeeb H., Xiong, Huabao, Merad, Miriam, Alexandropoulos, Konstantina
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5121015/
https://ncbi.nlm.nih.gov/pubmed/27543048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2016.08.002
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