Medullary thymic epithelial cell depletion leads to autoimmune hepatitis

TRAF6, an E3 ubiquitin protein ligase, plays a critical role in T cell tolerance by regulating medullary thymic epithelial cell (mTEC) development. mTECs regulate T cell tolerance by ectopically expressing self-antigens and eliminating autoreactive T cells in the thymus. Here we show that mice with...

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Detalhes bibliográficos
Main Authors: Bonito, Anthony J., Aloman, Costica, Fiel, M. Isabel, Danzl, Nichole M., Cha, Sungwon, Weinstein, Erica G., Jeong, Seihwan, Choi, Yongwon, Walsh, Matthew C., Alexandropoulos, Konstantina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726151/
https://ncbi.nlm.nih.gov/pubmed/23867620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65414
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