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Deficiency in Expression of the Signaling Protein Sin/Efs Leads to T-Lymphocyte Activation and Mucosal Inflammation

Our studies have concentrated on elucidating the role of the signaling protein Sin in T-lymphocyte function. We have previously shown that Sin overexpression inhibits T-lymphocyte development and activation. Here we show that Sin-deficient mice exhibit exaggerated immune responses characterized by e...

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Detalhes bibliográficos
Main Authors: Donlin, Laura T., Danzl, Nichole M., Wanjalla, Celestine, Alexandropoulos, Konstantina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316950/
https://ncbi.nlm.nih.gov/pubmed/16314525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.24.11035-11046.2005
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