Medullary thymic epithelial cell depletion leads to autoimmune hepatitis

TRAF6, an E3 ubiquitin protein ligase, plays a critical role in T cell tolerance by regulating medullary thymic epithelial cell (mTEC) development. mTECs regulate T cell tolerance by ectopically expressing self-antigens and eliminating autoreactive T cells in the thymus. Here we show that mice with...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Bonito, Anthony J., Aloman, Costica, Fiel, M. Isabel, Danzl, Nichole M., Cha, Sungwon, Weinstein, Erica G., Jeong, Seihwan, Choi, Yongwon, Walsh, Matthew C., Alexandropoulos, Konstantina
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726151/
https://ncbi.nlm.nih.gov/pubmed/23867620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65414
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires