Novel mechanism of modulation at a ligand‐gated ion channel; action of 5‐Cl‐indole at the 5‐HT(3)A receptor

BACKGROUND AND PURPOSE: The 5‐HT(3) receptor is a prototypical member of the Cys‐loop ligand‐gated ion channel (LGIC) superfamily and an established therapeutic target. In addition to activation via the orthosteric site, receptor function can be modulated by allosteric ligands. We have investigated...

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Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Powell, Andrew D, Grafton, Gillian, Roberts, Alexander, Larkin, Shannon, O'Neill, Nathanael, Palandri, Josephine, Otvos, Reka, Cooper, Alison J, Ulens, Chris, Barnes, Nicholas M
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5120152/
https://ncbi.nlm.nih.gov/pubmed/27677804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13638
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