Novel mechanism of modulation at a ligand‐gated ion channel; action of 5‐Cl‐indole at the 5‐HT(3)A receptor

BACKGROUND AND PURPOSE: The 5‐HT(3) receptor is a prototypical member of the Cys‐loop ligand‐gated ion channel (LGIC) superfamily and an established therapeutic target. In addition to activation via the orthosteric site, receptor function can be modulated by allosteric ligands. We have investigated...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Powell, Andrew D, Grafton, Gillian, Roberts, Alexander, Larkin, Shannon, O'Neill, Nathanael, Palandri, Josephine, Otvos, Reka, Cooper, Alison J, Ulens, Chris, Barnes, Nicholas M
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5120152/
https://ncbi.nlm.nih.gov/pubmed/27677804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13638
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