5-Chloroindole: a potent allosteric modulator of the 5-HT(3) receptor

BACKGROUND AND PURPOSE: The 5-HT(3) receptor is a ligand-gated ion channel that is modulated allosterically by various compounds including colchicine, alcohols and volatile anaesthetics. However the positive allosteric modulators (PAMs) identified to date have low affinity, which hinders investigati...

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Detalhes bibliográficos
Main Authors: Newman, Amy S, Batis, Nikolaos, Grafton, Gillian, Caputo, Francesca, Brady, Catherine A, Lambert, Jeremy J, Peters, John A, Gordon, John, Brain, Keith L, Powell, Andrew D, Barnes, Nicholas M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831704/
https://ncbi.nlm.nih.gov/pubmed/23594147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12213
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