X-ray diffraction study of the binding of the antisickling agent 12C79 to human hemoglobin.

The hemoglobin binding site of the antisickling agent 12C79 has been determined by x-ray crystallography. 12C79 is recognized as one of the first molecules to reach clinical trials that was designed, de novo, from x-ray-determined atomic coordinates of a protein. Several previous attempts to verify...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Wireko, F C, Abraham, D J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1991
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51199/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2006159/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.6.2209
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