X-ray diffraction study of the binding of the antisickling agent 12C79 to human hemoglobin.
The hemoglobin binding site of the antisickling agent 12C79 has been determined by x-ray crystallography. 12C79 is recognized as one of the first molecules to reach clinical trials that was designed, de novo, from x-ray-determined atomic coordinates of a protein. Several previous attempts to verify...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
1991
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51199/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2006159/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.6.2209 |
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