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Comparative evaluation of the chemical stability of four well-defined IgG1 Fc glycoforms

As part of a series of papers in this special issue evaluating model IgG1-Fc glycoforms for biosimilarity analysis, three well-defined IgG1-Fc glycoforms (High mannose-Fc, Man5-Fc, GlcNAc-Fc), and a non-glycosylated Fc protein (N297Q-Fc) were examined in this work to elucidate chemical degradation p...

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Bibliografske podrobnosti
izdano v:J Pharm Sci
Main Authors: Mozziconacci, Olivier, Okbazghi, Solomon, More, Apurva S., Volkin, David B., Tolbert, Thomas, Schöneich, Christian
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118937/
https://ncbi.nlm.nih.gov/pubmed/26869420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2015.10.024
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