TWEAK-Fn14 Signaling Activates Myofibroblasts to Drive Progression of Fibrotic Kidney Disease

The identification of the cellular origins of myofibroblasts has led to the discovery of novel pathways that potentially drive myofibroblast perpetuation in disease. Here, we further investigated the role of innate immune signaling pathways in this process. In mice, renal injury-induced activation o...

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Détails bibliographiques
Publié dans:J Am Soc Nephrol
Auteurs principaux: Gomez, Ivan G., Roach, Allie M., Nakagawa, Naoki, Amatucci, Aldo, Johnson, Bryce G., Dunn, Kadeshia, Kelly, Mark C., Karaca, Gamze, Zheng, Timothy S., Szak, Suzanne, Peppiatt-Wildman, Claire M., Burkly, Linda C., Duffield, Jeremy S.
Format: Artigo
Langue:Inglês
Publié: American Society of Nephrology 2016
Sujets:
Basic Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118488/
https://ncbi.nlm.nih.gov/pubmed/27026366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015111227
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