TWEAK-Fn14 Signaling Activates Myofibroblasts to Drive Progression of Fibrotic Kidney Disease

The identification of the cellular origins of myofibroblasts has led to the discovery of novel pathways that potentially drive myofibroblast perpetuation in disease. Here, we further investigated the role of innate immune signaling pathways in this process. In mice, renal injury-induced activation o...

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Foilsithe in:J Am Soc Nephrol
Main Authors: Gomez, Ivan G., Roach, Allie M., Nakagawa, Naoki, Amatucci, Aldo, Johnson, Bryce G., Dunn, Kadeshia, Kelly, Mark C., Karaca, Gamze, Zheng, Timothy S., Szak, Suzanne, Peppiatt-Wildman, Claire M., Burkly, Linda C., Duffield, Jeremy S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Nephrology 2016
Ábhair:
Basic Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118488/
https://ncbi.nlm.nih.gov/pubmed/27026366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015111227
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