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APOL1-G0 or APOL1-G2 Transgenic Models Develop Preeclampsia but Not Kidney Disease
APOL1 risk variants are associated with kidney disease in blacks, but the mechanisms of renal injury associated with APOL1 risk variants are unknown. Because APOL1 is unique to humans and some primates, we created transgenic (Tg) mice using the promoter of nephrin-encoding Nphs1 to express the APOL1...
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| Publié dans: | J Am Soc Nephrol |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Nephrology
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5118487/ https://ncbi.nlm.nih.gov/pubmed/27026370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015111220 |
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