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The ubiquitin ligase HUWE1 regulates hematopoietic stem cell maintenance and lymphoid commitment
Hematopoietic stem cells (HSCs) are dormant in the bone marrow and can be activated in response to diverse stresses to replenish all blood cell types. Here we identify the ubiquitin ligase Huwe1 as a crucial regulator of HSC functions via its post-translational control of N-myc. We found Huwe1 to be...
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| Pubblicato in: | Nat Immunol |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5117833/ https://ncbi.nlm.nih.gov/pubmed/27668798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3559 |
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