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Discovery of MRSA active antibiotics using primary sequence from the human microbiome
Here, we present a natural product discovery approach whereby structures are bioinformatically predicted from primary sequence and produced by chemical synthesis (synthetic-bioinformatic natural products, syn-BNPs), circumventing the need for bacterial culture and gene expression. When applied to no...
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| הוצא לאור ב: | Nat Chem Biol |
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| Main Authors: | , , , , , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2016
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5117632/ https://ncbi.nlm.nih.gov/pubmed/27748750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2207 |
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