Discovery of MRSA active antibiotics using primary sequence from the human microbiome

Here, we present a natural product discovery approach whereby structures are bioinformatically predicted from primary sequence and produced by chemical synthesis (synthetic-bioinformatic natural products, syn-BNPs), circumventing the need for bacterial culture and gene expression. When applied to no...

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Vydáno v:Nat Chem Biol
Hlavní autoři: Chu, John, Vila-Farres, Xavier, Inoyama, Daigo, Ternei, Melinda, Cohen, Louis J., Gordon, Emma A., Reddy, Boojala Vijay B., Charlop-Powers, Zachary, Zebroski, Henry A., Gallardo-Macias, Ricardo, Jaskowski, Mark, Satish, Shruthi, Park, Steven, Perlin, David S., Freundlich, Joel S., Brady, Sean F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117632/
https://ncbi.nlm.nih.gov/pubmed/27748750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2207
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