The helminth product, ES-62 modulates dendritic cell responses by inducing the selective autophagolysosomal degradation of TLR-transducers, as exemplified by PKCδ

We have previously shown that ES-62, a phosphorylcholine (PC)-containing glycoprotein secreted by the parasitic filarial nematode Acanthocheilonema viteae targets dendritic cell (DC) responses, specifically by suppressing TLR4 signalling to inhibit Th1/Th17-driven inflammation. We have now investiga...

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Publicado no:Sci Rep
Main Authors: Eason, Russell J., Bell, Kara S., Marshall, Fraser A., Rodgers, David T., Pineda, Miguel A., Steiger, Christina N., Al-Riyami, Lamyaa, Harnett, William, Harnett, Margaret M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116678/
https://ncbi.nlm.nih.gov/pubmed/27869138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37276
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