Tropisetron Protects Against Acetaminophen-Induced Liver Injury via Suppressing Hepatic Oxidative Stress and Modulating the Activation of JNK/ERK MAPK Pathways

Objectives. To investigate the protective effects of tropisetron on acetaminophen- (APAP-) induced liver injury in a mice model. Methods. C57BL/6 male mice were given tropisetron (0.3 to 10 mg/kg) 30 minutes before a hepatotoxic dose of acetaminophen (300 mg/kg) intraperitoneally. Twenty hours after...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Liu, Fu-Chao, Lee, Hung-Chen, Liao, Chia-Chih, Li, Allen H., Yu, Huang-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116490/
https://ncbi.nlm.nih.gov/pubmed/27891510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/1952947
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