The MAP2K4/JNK/c-Jun Signaling Pathway Plays A Key Role In Dexmedetomidine Protection Against Acetaminophen-Induced Liver Toxicity

PURPOSE: Dexmedetomidine [DEX; (S)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole] is a selective α(2)-adrenergic receptor (α(2)-AR) agonist that attenuates the liver damage associated with local or systemic inflammation. However, it remains unclear whether DEX has protective effects against acetamino...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Chou, An-Hsun, Liao, Chia-Chih, Lee, Hung-Chen, Liou, Jiin-Tarng, Liu, Fu-Chao
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2019
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861533/
https://ncbi.nlm.nih.gov/pubmed/31814709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S215473
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