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Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid fed mouse model of cholestasis
Sirtuin1 (Sirt1, mammalian homolog of S. Cerevisiae enzyme Sir2) is a transcriptional and transactivational regulator of murine Fxr, which is the primary bile acid (BA) sensor, and critical regulator of BA metabolism in physiological and pathophysiological conditions. Previous studies have suggested...
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| Published in: | Hepatology |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5115990/ https://ncbi.nlm.nih.gov/pubmed/27639250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28826 |
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