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Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid fed mouse model of cholestasis
Sirtuin1 (Sirt1, mammalian homolog of S. Cerevisiae enzyme Sir2) is a transcriptional and transactivational regulator of murine Fxr, which is the primary bile acid (BA) sensor, and critical regulator of BA metabolism in physiological and pathophysiological conditions. Previous studies have suggested...
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| 出版年: | Hepatology |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5115990/ https://ncbi.nlm.nih.gov/pubmed/27639250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28826 |
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