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An Mcm10 mutant defective in ssDNA binding shows defects in DNA replication initiation

Mcm10 is an essential protein that functions to initiate DNA replication after the formation of the replication fork helicase. In this manuscript, we identified a budding yeast Mcm10 mutant (Mcm10-m2,3,4) that is defective in DNA binding in vitro. Moreover, this Mcm10-m2,3,4 mutant does not stimulat...

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Vydáno v:J Mol Biol
Hlavní autoři: Perez-Arnaiz, Patricia, Kaplan, Daniel L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5115986/
https://ncbi.nlm.nih.gov/pubmed/27751725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.10.014
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