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HMGA2 Moderately Increases Fetal Hemoglobin Expression in Human Adult Erythroblasts

Induction of fetal hemoglobin (HbF) has therapeutic importance for patients with beta-hemoglobin disorders. Previous studies showed that let-7 microRNAs (miRNAs) are highly regulated in erythroid cells during the fetal-to-adult developmental transition, and that targeting let-7 mediated the up-regul...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: de Vasconcellos, Jaira F., Lee, Y. Terry, Byrnes, Colleen, Tumburu, Laxminath, Rabel, Antoinette, Miller, Jeffery L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5115839/
https://ncbi.nlm.nih.gov/pubmed/27861570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166928
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