IGF2BP1 overexpression causes fetal-like hemoglobin expression patterns in cultured human adult erythroblasts

Here we investigated in primary human erythroid tissues a downstream element of the heterochronic let-7 miRNA pathway, the insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), for its potential to affect the hemoglobin profiles in human erythroblasts. Comparison of adult bone marrow to fet...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: de Vasconcellos, Jaira F., Tumburu, Laxminath, Byrnes, Colleen, Lee, Y. Terry, Xu, Pauline C., Li, May, Rabel, Antoinette, Clarke, Benjamin A., Guydosh, Nicholas R., Proia, Richard L., Miller, Jeffery L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514697/
https://ncbi.nlm.nih.gov/pubmed/28652347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609552114
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