Erythroid-Specific Expression of LIN28A Is Sufficient for Robust Gamma-Globin Gene and Protein Expression in Adult Erythroblasts

Increasing fetal hemoglobin (HbF) levels in adult humans remains an active area in hematologic research. Here we explored erythroid-specific LIN28A expression for its effect in regulating gamma-globin gene expression and HbF levels in cultured adult erythroblasts. For this purpose, lentiviral transd...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Lee, Y. Terry, de Vasconcellos, Jaira F., Byrnes, Colleen, Kaushal, Megha, Rabel, Antoinette, Tumburu, Laxminath, Allwardt, Joshua M., Miller, Jeffery L.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684222/
https://ncbi.nlm.nih.gov/pubmed/26675483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144977
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