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Native functionality in triple catalytic cross-coupling: sp(3) C–H bonds as latent nucleophiles

The use of sp(3) C–H bonds—which are ubiquitous in organic molecules—as latent nucleophile equivalents for transition metal–catalyzed cross-coupling reactions has the potential to substantially streamline synthetic efforts in organic chemistry while bypassing substrate activation steps. Through the...

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Udgivet i:Science
Main Authors: Shaw, Megan H., Shurtleff, Valerie W., Terrett, Jack A., Cuthbertson, James D., MacMillan, David W. C.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114852/
https://ncbi.nlm.nih.gov/pubmed/27127237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf6635
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