Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation

Vascular cell hyperproliferation and metabolic reprogramming contribute to the pathophysiology of pulmonary arterial hypertension (PAH). An important cause of PAH in children with congenital heart disease (CHD) is increased pulmonary blood flow (PBF). To better characterize this disease course we st...

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Veröffentlicht in:Am J Physiol Heart Circ Physiol
Hauptverfasser: Boehme, Jason, Sun, Xutong, Tormos, Kathryn V., Gong, Wenhui, Kellner, Manuela, Datar, Sanjeev A., Kameny, Rebecca Johnson, Yuan, Jason X.-J., Raff, Gary W., Fineman, Jeffrey R., Black, Stephen M., Maltepe, Emin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114466/
https://ncbi.nlm.nih.gov/pubmed/27591215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00040.2016
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