Mesenchymal Stromal Cell-derived Extracellular Vesicles Promote Myeloid-biased Multipotent Hematopoietic Progenitor Expansion via Toll-Like Receptor Engagement

Mesenchymal stromal cells (MSCs) present in the bone marrow microenvironment secrete cytokines and angiogenic factors that support the maintenance and regenerative expansion of hematopoietic stem and progenitor cells (HSPCs). Here, we tested the hypothesis that extracellular vesicles (EVs) released...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Goloviznina, Natalya A., Verghese, Santhosh Chakkaramakkil, Yoon, Young me, Taratula, Oleh, Marks, Daniel L., Kurre, Peter
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114412/
https://ncbi.nlm.nih.gov/pubmed/27758863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.745653
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