Mesenchymal Stromal Cell-derived Extracellular Vesicles Promote Myeloid-biased Multipotent Hematopoietic Progenitor Expansion via Toll-Like Receptor Engagement

Mesenchymal stromal cells (MSCs) present in the bone marrow microenvironment secrete cytokines and angiogenic factors that support the maintenance and regenerative expansion of hematopoietic stem and progenitor cells (HSPCs). Here, we tested the hypothesis that extracellular vesicles (EVs) released...

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Vydáno v:J Biol Chem
Hlavní autoři: Goloviznina, Natalya A., Verghese, Santhosh Chakkaramakkil, Yoon, Young me, Taratula, Oleh, Marks, Daniel L., Kurre, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114412/
https://ncbi.nlm.nih.gov/pubmed/27758863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.745653
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