Endogenous DNA Damage Leads to p53-Independent Deficits in Replicative Fitness in Fetal Murine Fancd2(−/−) Hematopoietic Stem and Progenitor Cells

Our mechanistic understanding of Fanconi anemia (FA) pathway function in hematopoietic stem and progenitor cells (HSPCs) owes much to their role in experimentally induced DNA crosslink lesion repair. In bone marrow HSPCs, unresolved stress confers p53-dependent apoptosis and progressive cell attriti...

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Vydáno v:Stem Cell Reports
Hlavní autoři: Yoon, Young me, Storm, Kelsie J., Kamimae-Lanning, Ashley N., Goloviznina, Natalya A., Kurre, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5106485/
https://ncbi.nlm.nih.gov/pubmed/27720904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.09.005
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