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Endogenous DNA Damage Leads to p53-Independent Deficits in Replicative Fitness in Fetal Murine Fancd2(−/−) Hematopoietic Stem and Progenitor Cells
Our mechanistic understanding of Fanconi anemia (FA) pathway function in hematopoietic stem and progenitor cells (HSPCs) owes much to their role in experimentally induced DNA crosslink lesion repair. In bone marrow HSPCs, unresolved stress confers p53-dependent apoptosis and progressive cell attriti...
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| Yayımlandı: | Stem Cell Reports |
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| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Elsevier
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5106485/ https://ncbi.nlm.nih.gov/pubmed/27720904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.09.005 |
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