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Endogenous DNA Damage Leads to p53-Independent Deficits in Replicative Fitness in Fetal Murine Fancd2(−/−) Hematopoietic Stem and Progenitor Cells
Our mechanistic understanding of Fanconi anemia (FA) pathway function in hematopoietic stem and progenitor cells (HSPCs) owes much to their role in experimentally induced DNA crosslink lesion repair. In bone marrow HSPCs, unresolved stress confers p53-dependent apoptosis and progressive cell attriti...
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| Publicat a: | Stem Cell Reports |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5106485/ https://ncbi.nlm.nih.gov/pubmed/27720904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.09.005 |
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