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Short-lived Antigen Recognition but not Viral Infection at a Defined Checkpoint Programs Effector CD4 T Cells to become Protective Memory()

While memory CD4 T cells are critical for effective immunity to pathogens, the mechanisms underlying their generation are still poorly defined. We find that following murine influenza infection, most effector CD4 T cells undergo apoptosis unless they encounter cognate Ag at a defined stage near the...

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Bibliografske podrobnosti
izdano v:J Immunol
Main Authors: Bautista, Bianca L., Devarajan, Priyadharshini, McKinstry, K. Kai, Strutt, Tara M., Vong, Allen, Jones, Michael, Kuang, Yi, Mott, Daniel, Swain, Susan L.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113829/
https://ncbi.nlm.nih.gov/pubmed/27798159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600838
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