Use of Therapeutic Drug Monitoring, Electronic Health Record Data, and Pharmacokinetic Modeling to Determine the Therapeutic Index of Phenytoin and Lamotrigine

BACKGROUND: Defining a drug's therapeutic index (TI) is important for patient safety and regulating the development of generic drugs. For many drugs, the TI is unknown. A systematic approach was developed to characterize the TI of a drug using therapeutic drug monitoring and electronic health r...

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Detalhes bibliográficos
Publicado no:Ther Drug Monit
Main Authors: Ku, Lawrence C., Wu, Huali, Greenberg, Rachel G., Hill, Kevin D., Gonzalez, Daniel, Hornik, Christoph P., Berezny, Alysha, Guptill, Jeffrey T., Jiang, Wenlei, Zheng, Nan, Cohen-Wolkowiez, Michael, Melloni, Chiara
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113813/
https://ncbi.nlm.nih.gov/pubmed/27764025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FTD.0000000000000354
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