In vitro prion-like behaviour of TDP-43 in ALS

Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease (MND), and > 95% of familial and sporadic cases involve the deposition of insoluble aggregated, phosphorylated and cleaved TDP-43 protein. Accumulating clinical and biological evidence now indicates that ALS bears...

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Udgivet i:Neurobiol Dis
Main Authors: Smethurst, Phillip, Newcombe, Jia, Troakes, Claire, Simone, Roberto, Chen, Yun-Ru, Patani, Rickie, Sidle, Katie
Format: Artigo
Sprog:Inglês
Udgivet: Academic Press 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113659/
https://ncbi.nlm.nih.gov/pubmed/27590623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.08.007
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