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Functional Effect of the Mutations Similar to the Cleavage during Platelet Activation at Integrin β3 Cytoplasmic Tail when Expressed in Mouse Platelets

Previous studies in Chinese hamster ovary cells showed that truncational mutations of β3 at sites of F(754) and Y(759) mimicking calpain cleavage regulate integrin signaling. The roles of the sequence from F(754) to C-terminus and the conservative N(756)ITY(759) motif in platelet function have yet t...

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التفاصيل البيبلوغرافية
الحاوية / القاعدة:	PLoS One
المؤلفون الرئيسيون:	Shi, Xiaofeng, Yang, Jichun, Cui, Xiongying, Huang, Jiansong, Long, Zhangbiao, Zhou, Yulan, Liu, Ping, Tao, Lanlan, Ruan, Zheng, Xiao, Bing, Zhang, Wei, Li, Dongya, Dai, Kesheng, Mao, Jianhua, Xi, Xiaodong
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Public Library of Science 2016
الموضوعات:	Research Article
الوصول للمادة أونلاين:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5112943/ https://ncbi.nlm.nih.gov/pubmed/27851790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166136
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Functional Effect of the Mutations Similar to the Cleavage during Platelet Activation at Integrin β3 Cytoplasmic Tail when Expressed in Mouse Platelets

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