Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting

Abstract Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit bioinformation bidirectionally across the plasma membrane. Integrin αIIbβ3 is expressed at a high level in platelets and their progenitors, where it plays a central role in platelet functions, hemosta...

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Detalhes bibliográficos
Main Authors: Jiansong Huang, Xia Li, Xiaofeng Shi, Mark Zhu, Jinghan Wang, Shujuan Huang, Xin Huang, Huafeng Wang, Ling Li, Huan Deng, Yulan Zhou, Jianhua Mao, Zhangbiao Long, Zhixin Ma, Wenle Ye, Jiajia Pan, Xiaodong Xi, Jie Jin
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-03-01
Colecção:Journal of Hematology & Oncology
Assuntos:
Integrin αIIbβ3
Signal transduction
Talin
Kindlin
Transmembrane proteins
Therapeutic targeting
Acesso em linha:http://link.springer.com/article/10.1186/s13045-019-0709-6
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