Inhibition of CPT1a as a prognostic marker can synergistically enhance the antileukemic activity of ABT199

BACKGROUND: Fatty acid oxidation (FAO) provides an important source of energy to promote the growth of leukemia cells. Carnitine palmitoyltransferase 1a(CPT1a), a rate-limiting enzyme of the essential step of FAO, can facilitate cancer metabolic adaptation. Previous reports demonstrated that CPT1a a...

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Bibliographic Details
Published in:J Transl Med
Main Authors: Mao, Shihui, Ling, Qing, Pan, Jiajia, Li, Fenglin, Huang, Shujuan, Ye, Wenle, Wei, Wenwen, Lin, Xiangjie, Qian, Yu, Wang, Yungui, Huang, Xin, Huang, Jiansong, Wang, Jinghan, Jin, Jie
Format: Artigo
Language:Inglês
Published: BioMed Central 2021
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8082622/
https://ncbi.nlm.nih.gov/pubmed/33926484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-021-02848-9
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