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Functional Effect of the Mutations Similar to the Cleavage during Platelet Activation at Integrin β3 Cytoplasmic Tail when Expressed in Mouse Platelets

Previous studies in Chinese hamster ovary cells showed that truncational mutations of β3 at sites of F(754) and Y(759) mimicking calpain cleavage regulate integrin signaling. The roles of the sequence from F(754) to C-terminus and the conservative N(756)ITY(759) motif in platelet function have yet t...

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Publicado en:PLoS One
Main Authors: Shi, Xiaofeng, Yang, Jichun, Cui, Xiongying, Huang, Jiansong, Long, Zhangbiao, Zhou, Yulan, Liu, Ping, Tao, Lanlan, Ruan, Zheng, Xiao, Bing, Zhang, Wei, Li, Dongya, Dai, Kesheng, Mao, Jianhua, Xi, Xiaodong
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5112943/
https://ncbi.nlm.nih.gov/pubmed/27851790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166136
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