Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II

BACKGROUND: Lapachol is a natural naphthoquinone compound that possesses extensive biological activities. The aim of this study is to investigate the inhibitory effects of lapachol on rat C6 glioma both in vitro and in vivo, as well as the potential mechanisms. METHODS: The antitumor effect of lapac...

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Bibliografiske detaljer
Udgivet i:J Exp Clin Cancer Res
Main Authors: Xu, Huanli, Chen, Qunying, Wang, Hong, Xu, Pingxiang, Yuan, Ru, Li, Xiaorong, Bai, Lu, Xue, Ming
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5112657/
https://ncbi.nlm.nih.gov/pubmed/27852319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-016-0455-3
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