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Deregulation of the Hippo pathway in mouse mammary stem cells promotes mammary tumorigenesis
The Hippo-YAP pathway mediates organ size control, contact inhibition, and tumorigenesis. It is a kinase cascade that inhibits the nuclear localization and transcriptional activities of YAP and TAZ. E-cadherin, cell junctions, polarity proteins, and the merlin/NF2 tumor suppressor activate the pathw...
Guardat en:
| Publicat a: | Mamm Genome |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5112122/ https://ncbi.nlm.nih.gov/pubmed/27601049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00335-016-9662-7 |
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